New Study: Prebiotic PreforPro® Shows Synbiotic Benefits for GI Function

Deerland Probiotics and Enzymes has announced the publication of a human clinical trial demonstrating the synbiotic benefits of PreforPro®, a unique and proprietary blend of bacteriophages, in promoting the balance of good bacteria in the microbiome.

The goal of the parallel-arm study was to investigate whether adding bacteriophages with a probiotic would provide additional benefits to gastrointestinal function as well as augment the microbiota in the gut compared to the probiotic by itself, suggesting a truly synergistic capability.

The study, “PHAGE-2 Study: Supplemental Bacteriophages Extend Bifidobacterium animalis subsp. lactis BL04 Benefits on Gut Health and Microbiota”, published in Nutrients, was a randomized, double-blind, placebo-controlled clinical intervention trial. In this study, 66 participants were randomly assigned to one of three groups: placebo; Bifidobacterium animalis BL04 (B. lactis BL04) 1 billion CFU; or B. lactis BL04 (1 billion CFU) plus PreforPro (15mg). Participants consumed one capsule per day for four weeks. The outcomes sought were impacts on GI discomfort as well as changes or modulation of the gut microbiota.

Overall, the researchers found that the individuals in the B. lactis plus PreforPro group showed the following:

  • Improvements in self-reported GI inflammation symptoms
  • Reduction in colonic cramp discomfort
  • Greater increase in the presence of Lactobacillus vs. placebo
  • Decrease of strains Citrobacter and Desulfovibrio, which are associated with gut inflammation and GI disorders
  • Reduction in E. coli

In conclusion, the study demonstrates that supplementing B. lactis BL04 with PreforPro can significantly modulate gut ecology to favor beneficial bacteria. “In addition, a lack of global changes to the microbiota (dysbiosis) in combination with specific modulation of certain taxa, like Lactobacillus, suggests that PreforPro displays prebiotic-like effects and may extend the GI benefits of consuming B. lactis or other probiotics.,” says John Deaton, vice president of science and technology for Deerland Probiotics & Enzymes.

“This study demonstrates the opportunity and capability of phages in the robust support of healthy microflora balance and the associated physiological benefits. Phages are clearly up-and-coming supplements in the rapidly burgeoning arena of microbiome support.”