MuniSpore® is the probiotic strain Bacillus clausii CSI08, a soil-based microorganism. Species of Bacillus are among the most widespread microorganisms in nature and have a long history of safe use, with B. clausii shown to be present in whole grain products and fermented foods and beverages. The beneficial effects of the probiotic B. clausii have been attributed to its ability to positively influence microbial populations and immune function.


The human body carries nearly 100 trillion bacteria in the gut…that’s more than 10 times the total number of human cells in the entire body. Probiotics are those “good” bacteria that help keep the intestines healthy and assist in digestion and nutrient absorption. Researchers are also finding evidence that certain bacteria in the gut influence the development of aspects of the immune system. In fact, about 70% of the immune system is housed in the gut.

The health benefits of the probiotic Bacillus clausii include:

  • Crowds out bacterial pathogens and maintains healthy gut flora
  • Supports the normal immune reaction of intestinal cells
  • Supports the body’s natural repair system through antioxidant activity
  • Can persist in the GI tract, increase its numbers and then re-sporulate



Ciprandi, G et al. (2005) Allergy 2005a;60:702–3.
Ciprandi, G et al. (2005) Eur Ann Allergy Clin Immunol. 2005b;37:129–33.
Urdaci MC, et al. (2004) J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S86-90.
Gabrielli M, et al. (2009) Am J Gastroenterol. May;104(5):1327-8.


Oxidants are reactive molecules that are produced inside the body that damage other healthy cells like proteins, DNA, and lipids. This damage, called oxidative stress, affects the immune system and is often the cause of inflammation, illness, and various negative health conditions. Antioxidants can scavenge these reactive molecules and minimize cellular damage, supporting the body’s natural repair mechanism. The consumption of probiotics, such as Lactobacilli, has been shown to increase antioxidant activity in the body.

Total antioxidant capacity (TAC) demonstrates a material’s ability to counteract oxidative stress-induced damage in cells.  The TAC level of the probiotic MuniSpore is significantly higher than that of a well-known Lactobacillus probiotic strain.

The antioxidant activity of MuniSpore suggests the mechanism of action for the immune health benefits exhibited by this probiotic strain.

Khokhlova, E et al. (2023) Microorganisms 2023, 11, 240.


Spore forming bacteria are a diverse group of very hardy bacteria, characterized by their ability to form endospores to protect themselves in varying conditions such as high temperatures and the acidic environment of the gut.

Bacillus clausii has the ability to form spores that protect the microbes from harsh conditions until they enter an environment ripe for germination, such as the GI tract.  This means that MuniSpore remains viable under a wide temperature range and doesn’t require refrigeration.  It also survives passage through the acidic environment of the GI tract.

Because MuniSpore remains viable under a wide temperature and pH range, the probiotic is ideal for use in supplements, foods and beverages.


More than 20 pre-clinical and in vitro studies have been performed to confirm the safety and efficacy of MuniSpore Bacillus clausii CSI08.  A full genome sequencing confirmed the strain contained no plasmids, antibiotic resistant or deleterious genes. The genome sequence of MuniSpore has been uploaded to GenBank, the National Institutes of Health genetic sequence database.


  • Supplement Capsules, Tablets and Bulk Powder Blends
  • Stick Packs
  • Gummies
  • Food and Beverage


  • Kosher
  • GRAS Status